Tignanello is produced exclusively from the vineyard of the same name, a parcel of some 140 acres (57 hectares) with limestone-rich soils and a southwestern exposure at 1150-1325 feet (350-400 meters) above sea level at the Tignanello estate.

It was the first Sangiovese wine to be aged in small oak barrels, the first modern red wine in the region to use such non-traditional varieties as Cabernet in the blend, and among the first red wines from the Chianti Classico area to be produced without white grapes.

The wine, originally called "Chianti Classico Riserva vigneto Tignanello" (a Chianti Classico Riserva from the Tignanello vineyard), was produced for the first time from a single vineyard parcel in 1970, when the blend contained 20% of Canaiolo and 5% of Trebbiano and Malvasia, both white grapes, and the wine aged in small oak barrels.

In 1971, it became a Tuscan red table wine rather than a Chianti Classico and was called Tignanello. In the 1975 vintage, the percentage of white grapes was definitively eliminated from the blend. Ever since 1982, the blend has been the one currently used. Tignanello is bottled only in favorable vintages, and was not produced in 1972, 1973, 1974, 1976, 1984, 1992, and 2002.

The 2021 Antinori Tignanello IGT is a proprietary blend from Tuscany, Italy. This red wine, produced by Antinori, features a blend of 79% Sangiovese, 13% Cabernet Sauvignon, and 8% Cabernet Franc. This vintage marks the 50th anniversary of the first Tignanello, made in 1971. The 2021 vintage has been well-received by professional reviewers, garnering high scores and praise for its structure and flavor profile.

James Suckling awarded this wine a score of 96, highlighting its "currants and spices," along with "hazelnut undertones." He describes it as "medium- to full-bodied with juicy tannins and a flavorful finish." Suckling further notes that it is "very structured for a Tignanello," with "medium chewy tannins" and a "deft winemaking hand coming through." He suggests that while it needs "three or four years to soften," all the elements are present for an excellent wine.

Robert Parker's Wine Advocate gave an exceptional score of 98, celebrating the wine's 50th birthday. The publication described it as pulling "on all the heartstrings," with flavors of "tart fruit, redcurrant, tea leaf, heritage rose, crushed white pepper, licorice, nutmeg, clove, and chopped mint." The review notes that the wine "opens slowly to reveal more richness and exuberance with time," becoming "voluptuous and heady." It emphasizes the "bright freshness and minerality of Sangiovese," and compares it favorably to the 2018 vintage, noting that the 2021 has "more overall fruit weight and volume."

Vinous also awarded the wine a score of 98, calling it "every bit as impressive from bottle as it was from barrel." The review describes the wine as "silky and polished, with exceptional finesse," and states that it has the "pedigree to become a modern benchmark for Tignanello and Italian wine more broadly." The tasting notes include "bright dark red fruit, blood orange, spice, cedar, and sweet pipe tobacco," framed by "a discreet touch of French oak." It is noted that the wine spent "17 months in wood, three months in neutral oak during the malolactic fermentation, and then 14 months (50% new) for the rest of its aging."

Overall, the 2021 Antinori Tignanello IGT has been praised for its structure, flavor complexity, and potential for aging, making it a celebrated addition to Antinori's storied history.